tag:blogger.com,1999:blog-5002675950760488813.post3389319677094205971..comments2024-01-21T14:11:10.779-08:00Comments on The Unsilenced Science: The Politically Incorrect Guide to Weight Lossnooffensebuthttp://www.blogger.com/profile/02461190919466049463noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-5002675950760488813.post-82414382626444548192023-08-14T07:29:33.532-07:002023-08-14T07:29:33.532-07:00Thannks for posting thisThannks for posting thisRoger Yang's Thought Bloghttps://dodgerroger.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-7510551058335659932012-10-20T05:45:57.553-07:002012-10-20T05:45:57.553-07:00I'll eat what I want. Period.I'll eat what I want. Period.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-68225817813884753092011-12-01T18:28:13.444-08:002011-12-01T18:28:13.444-08:00I believe I saw research once that showed listenin...I believe I saw research once that showed listening to music actually decreases exercise intensity, by creating cadences below optimal exertion.Chrishttps://www.blogger.com/profile/09148369137917100380noreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-10818875762905431772011-08-30T12:27:21.304-07:002011-08-30T12:27:21.304-07:00"Visscher and colleagues estimate 17% of the ..."Visscher and colleagues estimate 17% of the variance in height can "<br /><br />Should be "17% of the variance in BMI"n/ahttp://racehist.blogspot.comnoreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-30024404203552030772011-08-30T12:26:27.090-07:002011-08-30T12:26:27.090-07:00Visscher and colleagues estimate 17% of the varian...Visscher and colleagues <a href="http://www.ncbi.nlm.nih.gov/pubmed/21552263" rel="nofollow">estimate</a> 17% of the variance in height can be explained by common autosomal SNPs (compared to 40-50% for height and IQ).<br /><br />nooffensebut,<br /><br />Elsewhere, you posted: "I am all for conceptual simplicity, but I do<br />not understand why a program that weights variants according to maximum<br />predictive power is not value-added and within our capabilities with computers."<br /><br />If I understand what you're asking, they did basically do this in the IQ paper. The problem is the sample sizes are too small, and you can't extract more information than is there. So while it's possible to estimate 40-50% of variance in IQ is explainable by common SNPs (and in this analysis, the relatively small sample sizes just make the result less precise, not biased in any particular direction), when they attempt to use a model built using one set of samples to predict IQs in another sample, they can only predict something like 7-11% of variance right now.n/ahttp://racehist.blogspot.comnoreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-82473971092450745482011-08-29T23:51:03.187-07:002011-08-29T23:51:03.187-07:00Good question. The most recent review paper that ...Good question. The most recent review paper that I found, <a href="http://www.jci.org/articles/view/46044/files/pdf" rel="nofollow">Ramachandrappa and Farooqi</a>, says that “changes in environmental factors undoubtedly drive the rise in prevalence of obesity,” but “within a population the variance in BMI … is largely genetically determined with heritability estimates ranging between 40% and 70%.” After the current epidemic began, heritability estimates increased to 77%. If we were talking about height or IQ, then heritability would have more meaning in industrialized societies, but the “heritability of obesity” as something distinct from variant BMI response to an environmental epidemic makes less sense in wealthy Western societies.nooffensebuthttps://www.blogger.com/profile/02461190919466049463noreply@blogger.comtag:blogger.com,1999:blog-5002675950760488813.post-78996391451335714952011-08-29T17:46:42.220-07:002011-08-29T17:46:42.220-07:00How heritable is obesity?How heritable is obesity?TGGPhttps://www.blogger.com/profile/11017651009634767649noreply@blogger.com